Notes to myself

An effort to extend the time between the recently learned and soon forgotten

April, 2015

Capitalism and weather

Naomi Klein's latest book "This changes everything" charges in and boldly states that free-market capitalism is incompatible with a sustainable approach to energy consumption. The book is excellent, and goes well beyond the usual descriptions of environmental change, and instead explores why the response to this problem has thus far been so underwhelming. The reasons behind the tepid response, and why the US in particular has had such a difficult time accepting the notion, trace back to questions of culture, power, and money. Klein points out that politicians and activists alike seem anxious to present climate change as a business opportunity with economic benefits for everyone. The fact that this sort of framing is necessary implies that money and power might appropriately outweigh concerns such the maintenance of a functional bio-system and the availability of clean water. What if the changes necessary to slow climate change do not represent an economic 'win-win situation', but are necessary to save the planet? It's hard to imagine why any further justifications would be necessary to move to more sustainable basis for development.

Antibiotic resistance among the Yanomami

In 2008 some Venezuelan paratroopers spotted a previously unknown Yanomami village deep in the forest on the side of a mountain. People who have had no contact with the industrialized world are of particular interest to scientists who study the organisms living in our guts, since it is otherwise difficult to determine the nature of our pre-industrialization microbiome. It is now entirely routine for children to receive multiple regimens of antibiotics during their early years in response to strep throat, earaches, or a variety of other ailments. Furthermore our gut microbes are impacted by the insecticides and industrial pollutants that pervade our environment. These chemicals combine with a diet of highly processed food to create conditions for the microorganisms living inside us that are quite unlike the those of our evolutionary ancestors. Therefore a village full of people who have not experienced these types of exposures can provide a window into some of the changes that industrialization must have wrought on the 1.5 kilograms of microorganisms that live inside us.

The investigation of the people in this village began in 2009, based on bacteria collected from the feces, skin, and mouths of village members. The genetic sequences of these bacteria demonstrated that their populations were significantly more diverse than the population of typical Westerners, with many strains that were missing entirely from their Western counterparts. Medical workers documented that while the Yanomami had many parasites, they were generally healthy, and that diseases such as diabetes, heart disease, and autoimmune disorders were notably absent among the villagers. Also noted among these bacteria, however, were a surprising number of genes for antibiotic resistance. Why would persons who have never been exposed to Western medicines or diet carry bacteria with nearly 60 unique genes capable of combating, among other things, modern, synthetic antibiotic drugs?

The issue is that bacteria have long been warring against other organisms, notably among them fungi found in the soil. Antibiotic drugs have often been extracted directly (or else structurally derived) from fungi found in the soil. Therefore the problem of antibiotic resistance is likely to be even more challenging than scientists had previously understood. Bacteria need not invent some completely novel mechanism in order to fight back against a newly developed antibiotic. Instead bacteria can often switch on latent resistance already resident in their genomes. And given prokaryotic organisms' facility for incorporating external DNA strands, if any bacteria knows how to fight a drug then they will often share that ability with other microorganisms. This information should make us redouble our efforts to use antibiotics very conservatively, to fund programs for new antibiotic development, and to immediately stop incorporating low levels of antibiotics into domestic animal feed. The inactivation of antibiotic drugs looms as one of the great threats to public health of this century, and anything we can do to help allay this crisis is worth considering.

Click here to read more about the original study, or here to read a news report describing the study.